The Impact on Multiple Ligands for Receptor of Advanced Glycation End Products with Linagliptin
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چکیده
The malnutrition-inflammation-atherosclerosis syndrome is an important prognostic factor for hemodialysis (HD) patients. Linagliptin is a bile-excreted dipeptidyl peptidase (DPP)-4 inhibitor, and therefore, dose reduction is not necessary for HD patients. The anti-inflammatory effects of linagliptin were reported in HD patients, and linagliptin may also prevent systemic atherosclerosis. Advanced glycation end products (AGEs)-receptor for AGEs (RAGE) signals as well as inflammation are important and well-known atherosclerotic factors. In this study, we examined the influence of linagliptin on multiple RAGE ligands to further investigate the anti-atherosclerotic mechanism of linagliptin in HD patients.
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تاریخ انتشار 2015